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The proteins talin and vinculin are two of many proteins involved in mammalian cell-matrix adhesion. Write a short research proposal of

The proteins talin and vinculin are two of many proteins involved in mammalian cell-

matrix adhesion. Write a short research proposal of two-pages to determine their

interactions and their complex structure, using the EXPERIMENTAL METHODS you

learned from this class.

(The experimental method learned in class are the following:)

● Spectroscopy
● Fluorescence spectroscopy
● Light Scaterring
● NMR
● Cristal chromatography

The proposal should include:

1) Introduction, state the biological importance or significance of the proteins

and their interactions (10 points)

2) What do you propose to study, and why? (10 point)

3) Potential significance of your proposed research (10 points)

4) Experimental design, propose to use 2-3 methods that we have learned in

Chem43500 (30 points)

5) Expected results of your proposed experiments (30 points)

References should be included as additional pages. Typed answer is required.

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